Description
Epigenetics is defined as the study heritable alterations in gene function that occur without underlying changes in DNA sequence. Biologically, aging is linked with a gradual increase in molecular and cellular damage eventually leading to a decline in physiological reserves and an increased risk of developing diseases. It is now well established that a vast number of epigenetic changes, notably DNA methylation occur during the aging process.
Epigenetic changes offer the potential for maintaining health or reversing diseases by modulating the function of druggable proteins coded by genes with dynamic and reversible methylation changes.
Keywords
Epigenetics
Aging
Drug discovery
Disease
Drug targets
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Author
Sheraz Gul
(Fraunhofer Institute)
Co-authors
Mr
Andrea Zaliani
(Fraunhofer Institute)
Dr
Carsten Claussen
(Fraunhofer Institute)
Mr
Ferdinand Seum
(Fraunhofer Institute)
Mr
Jaleed Aslam
(Cerascreen GmbH)
Mr
Olaf Schneider
(Cerascreen GmbH)
Dr
Philip Groth
(Cerascreen GmbH)
Dr
Sung-Min Pyo
(Pyo Labs Ltd)
Ms
Tara Beirne
(University of Ireland, Galway)
Dr
Wilfried Blum
(Cerascreen GmbH)