Description
The outbreak of Mpox virus (MPXV) infection in May 2022 is declared a global health emergency by WHO. The MPXV pathophysiology and its underlying mechanisms are not yet understood. Likewise, the knowledge of biochemicals and drugs used against MPXV and their downstream effects is sparse. Using systems biology approaches, we used Knowledge Graph (KG) representations to depict chemical and biological aspects of MPXV. We collected and rationally assembled biological study results, assays, drug candidates, and pre-clinical evidence to form a dynamic and comprehensive network. The KG is compliant with FAIR principles allowing seamless transformation and integration to/with other formats and infrastructures. Its implementation in Mpox was the first usecase of this workflow and can be used for other infectious diseases.
Keywords
knowledge graph
mpox
infectious disease
| Find me @ my poster | Reagon Karki |
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