Aug 25 – 29, 2025
Lecture Hall D
Europe/Berlin timezone

Enhanced usage of top-down data for de novo sequencing of antibodies

Aug 28, 2025, 4:50 PM
15m
VMP 6 / Philturm (Lecture Hall D)

VMP 6 / Philturm

Lecture Hall D

Von-Melle-Park 6 20146 Hamburg

Speaker

Kira Vyatkina (Sechenov University)

Description

The Twister algorithm (Vyatkina et al., 2015, 2016, 2017), initially intended for de novo sequencing of antibodies from top-down MS/MS data supported with high-resolution bottom-up MS/MS spectra, is being developed further – currently aiming, at particular, at taking the maximum profit from internal fragment ions. In this talk, we will present the latest version of the Twister algorithm, along with the most recent results obtained.

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Author

Kira Vyatkina (Sechenov University)

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